Installation on Windows 10

[cicko]

Nothing obvious to point out, unfortunately. GnuCash normally does not have
issues like that. You can try out a few things.
Can you save the book as sqlite database and open it?
Can you save the book through "save as" option and open it again?
Is there an antivirus or something else that might be locking the file? 
Do you have another instance of GnuCash running, using the same book?

You can also try a tool like Unlocker, Process Hacker, or Resource Monitor
and see which processes are using your database file.



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